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This article systematizes the objectives for the state regulation of regional development. We describe an ideal multiregional system model and analyze the barriers to an efficient regulation of regional development. We formulate approaches to evaluating the impact that a public socio-economic policy has on regional development. Here we propose a concept for coordinating macroeco-nomic and long-term regional solutions following the transfer of defining scenario conditions over the levels of the territorial hierarchy of the economy. We present a framework and structure for the four-level system of hierarchical calculation that assemble the outline of inter-level and horizontal data flows of incoming, defining and estimate indicators. As for the eastern regions of Russia, we provide a roadmap segment for transferring macroeconomic scenario conditions to the federal subject level and some test results