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The article claims that an effective use of the findings from a study of inno­vation in the reproduction process may result from revising the role of regions in the spatial diffusion of innovations. Regions are mostly able to develop actively various forms of cooperation, including ones with neighboring ter­ritories and foreign companies when these processes are systematically coor­dinated by the government and serve the interests of the entire Federation and not just individual regions with objective benefits or special investment support from the government. Converting regions into the drivers of innovative deve­lopment will require expanding their powers at least to the level stated in the Constitution of the Russian Federation as equal subjects of the Federation, obliged and able to guarantee the extended innovative development of an area. There is a need in elaborating, deliberating and implementing a national (federative) plan of innovative development of the country that will involve all federal subjects, municipalities, and market agents by selecting programs and business projects on a competitive basis. Economic science aims at formulating ways and methods to restore and strengthen the innovation-renovated manu­facturing status of Russia - by consolidating the community through systematic modernization, organizing innovatively active population, rationally distri­buting innovation powers and available resources among all the parties to socio-economic and social relationships.